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This research explores how microRNAs maintain the identity of adult β-cells and their role in preventing de-differentiation linked to type 2 diabetes. It aims to uncover genetic mechanisms that sustain cell identity over time.
Normal physiology depends on defined functional output of differentiated cells. A century of Developmental–Biology studies revealed diverse mechanisms for differentiation, however once ‘terminally’ differentiated, cells are thought to naïvely stay put.
However differentiated cells are surprisingly fragile, for example, phenotypic collapse and de–differentiation of β–cells was recently discovered in pathogenesis of type 2 diabetes.
These discoveries necessitate investigations of key questions:
Ho…
WEIZMANN INSTITUTE OF SCIENCE
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