CORDIS Project
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This project examines the role of microRNAs in the immune response to pathogenic bacteria in Crohn's disease. It aims to identify how these molecules influence host cell responses and could lead to new therapeutic targets.
Recent studies have shown dysregulation of microRNAs (miRNAs) in the mucosa of Crohn’s disease (CD) patients, suggesting a role for miRNAs as contributors to inflammatory bowel disease (IBD) susceptibility.
The scientists from the host institution previously showed that ileal lesions in CD patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC), which are able to invade and to replicate within intestinal epithelial cells, and that functional autophagy is required to restra…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Clermont-Ferrand
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
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