CORDIS Project
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This project investigates the mismatch repair system in DNA, focusing on its role in preventing mutations and its involvement in cancer. By exploring a newly identified non-canonical pathway, the research aims to enhance understanding of DNA repair mechanisms and their implications for human health.
The mismatch repair (MMR) system has evolved to correct errors of DNA replication and prevent recombination between non-homologous sequences.
Correspondingly, MMR malfunction leads to increased mutation rates and illegitimate recombination, and individuals with inherited MMR gene mutations are predisposed to cancer of the colon and other organs.
However, MMR has recently been implicated in processes ranging from DNA damage signaling and drug sensitivity to antibody maturation, some of which cont…
University of Zurich
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