CORDIS Project
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This project investigates the role of specific microRNAs in cancer, focusing on their regulation and function. By identifying factors that influence oncogenic microRNAs, the research aims to enhance understanding of cancer biology and develop potential therapeutic strategies to manipulate these molecules in disease con…
microRNAs (miRNAs) are master regulators of gene expression capable of defining and altering cell identity.
Because of their potency, small size, simple mode of action (target recognition through a Watson-Crick type of base pairing) and the possibility to inhibit them in vivo, miRNAs are valuable therapeutic targets.
Recently, we have used novel functional-genetic screening approaches and identified the miR-372, 373 and 520, as well as the miR-221&222 family as cancerous miRNAs.
These miRNAs are…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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