CORDIS Project
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This project investigates the role of ADAM10 and specific microRNAs in Alzheimer's disease and Type 2 diabetes. It aims to validate these microRNAs as potential biomarkers for diagnosis and prognosis, ultimately developing a diagnostic device that offers a less invasive and cost-effective approach.
ADAM10 (A Disintegrin and Metalloprotease 10), the main α-secretase of the non-amyloidogenic cleavage of the amyloid precursor protein (APP), is a common player in Type 2 diabetes (T2D) and Alzheimer´s disease (AD). ADAM10 levels are altered in platelets, plasma, serum, and CSF of elderly with AD, suggesting its potential role as an AD biomarker.
It is well known that there is an association between impaired insulin signaling and the amyloid cascade, as ADAM10 is also increased in T2D and insuli…
UNIVERSITAT DE BARCELONA
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