CORDIS Project
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This project aims to prevent delayed graft function in kidney transplantation by investigating the role of microRNA-182 in regulating inflammatory responses. It explores the potential of miR-182 inhibition as a therapeutic approach to improve transplant outcomes.
Delayed graft function (DGF) after kidney transplantation represents the main risk factor for allograft loss.
While DGF occurs rarely after living donor transplantation, about 25% of deceased donor kidney recipients develop DGF and require dialysis within the first week after transplantation.
Various molecular mechanisms have been elucidated.
Pro-inflammatory response after brain death and ischemic reperfusion injury are significant factors contributing to development of DGF.
Nevertheless, preve…
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