CORDIS Project
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This project investigates the mechanisms controlling cell division in the bacterium Caulobacter crescentus. It focuses on the role of the protein MipZ in regulating the division plane, utilizing various biochemical and imaging techniques to understand its interactions.
Correct positioning of the division plane is essential for the generation of normal offspring.
In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre.
Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell.
Gradient formation involves a dynamic localizatio…
PHILIPPS UNIVERSITAET MARBURG
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