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The MinorSplice project focuses on the minor spliceosome, a complex responsible for processing a small percentage of introns in human genes. By employing advanced imaging and proteomic techniques, the project aims to elucidate the structure and function of this spliceosome pathway, which is crucial for understanding ge…
Introns are non-coding segment of eukaryotic genes, which are removed from precursors of messenger RNAs (pre-mRNAs) by a large and dynamic RNA-protein complex known as the spliceosome.
In human cells, most of the introns are processed by the canonical U2-dependent, major spliceosome.
Around 0.5% of human introns utilise an alternative splicing pathway, catalysed by the minor spliceosome, which depends on the U12 small nuclear RNA (snRNA).
While U12-dependent introns are rare, often they are loca…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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