CORDIS Project
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This research investigates the role of microRNAs in neutrophils and their contribution to endothelial cell damage in anti-neutrophil cytoplasm antibody-associated vasculitis. The study aims to identify specific microRNAs that could serve as biomarkers and potential therapeutic targets for this condition.
Activation of neutrophils by ANCA (“Anti-Neutrophil Cytoplasm Antibodies”) and subsequent endothelial cell (EC) damage is the main feature of ANCA-associated vasculitis (AAV).
There is no specific treatment for AAV to date and 25% of patients evolve towards end-stage renal disease requiring dialysis and renal transplantation.
While accumulating data indicate that miRNAs control major biological responses in various cell types including EC and neutrophils and are involved in the pathophysiology o…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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