CORDIS Project
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This project investigates the role of the IRGQ protein in autophagy and its implications for neurodegenerative diseases. By exploring how IRGQ regulates cellular processes and immune responses, the research aims to identify new therapeutic targets for managing neuroinflammation and neurodegeneration.
Neurodegenerative diseases and chronic brain inflammation affect millions and still lack effective, mechanism-based treatments.
Failures in cellular quality control such as autophagy fuel neuro-inflammation and neuro-degeneration.
Our recent work (Herhaus, Cell 2024) identified IRGQ as a new autophagy receptor which directs cargo either to lysosomal degradation (degradative autophagy) or to membrane presentation and cell release (secretory autophagy). IRGQ is essential in maintaining membrane in…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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Germany, Mainz
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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