CORDIS Project
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This project aims to develop a new method for site-selective protein labeling using a non-canonical amino acid and rapid chemical reactions. The approach focuses on studying cellular processes like apoptosis with improved spatial and temporal resolution, which could enhance our understanding of biological mechanisms an…
Insight into dynamic processes such as uptake and intracellular trafficking and signalling of small molecules and proteins in cells is key in basic biology and drug development.
The use of bioorthogonal chemical reactions for labelling and probing specific biomolecules is an exciting option but a very challenging task as these transformations should proceed very rapidly in physiological conditions with complete chemoselectivity.
So, in this application we propose to achieve site-selective protei…
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