CORDIS Project
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This project investigates how the cytoskeleton influences nuclear mechanics and gene expression in response to mechanical stress. By developing a numerical model, it aims to understand the relationship between cellular forces and chromatin remodeling, with potential applications in disease treatment and cellular biolog…
The cytoskeleton plays a pivotal role in growth, development, and disease by sensing mechanical stress and mediating structural remodeling and cell functional responses.
The cytoskeleton, which is linked directly to the nuclear lamina and thereby to chromatin, has recently been proposed to impact on chromatin remodeling and transcriptional activity.
However, the mechanisms and biological consequences of force-dependent chromatin remodeling have remained elusive.
Within this context main goals fo…
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