CORDIS Project
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This project focuses on engineering biomimetic nanoparticles from human breast milk cells to enhance oral drug delivery. These nanoparticles aim to protect therapeutic agents from degradation in the gastrointestinal tract, improving treatment outcomes for large molecules.
We propose to use human breast milk cells to engineer breast milk biomimetic nanoparticles (NP), “MILKOSOMES,” to shuttle medicines orally into the body that, under other conditions, would not be able to distribute properly. MILKOSOMES are cellular membrane protein-functionalized phospho-lipid NP (i.e., liposomes), and they are hypothesized to cross the gastrointestinal (GI) tract while protecting their therapeutic cargo and serve as a novel way to improve oral therapy outcomes.
Unfortunately, a…
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