CORDIS Project
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This project investigates how immune cells, specifically germinal center B cells, adapt their metabolism in response to their microenvironment. It focuses on understanding mitochondrial dynamics and the influence of environmental metabolites on immune responses, particularly in the context of autoimmune diseases.
Immune responses occur in often highly compartmentalised tissue microenvironments, which in turndefine local metabolic conditions.
In the architecture of lymphoid tissue, very little is known aboutcellular metabolic interactions, or how immune cells adapt their metabolism in response to a changingenvironment.
The humoral immune response is essential for normal immunity, and its centrepiece isthe germinal centre (GC) reaction, which allows the generation of high-affinity antibodies and B cellmemo…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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