CORDIS Project
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This project investigates a newly identified proteostasis pathway, the Intracellular Pathogen Response, in mammalian cells during Microsporidia infections. By comparing this response to that in the model organism Caenorhabditis elegans, the research aims to enhance understanding of cellular protein regulation in health…
Cellular protein homeostasis (proteostasis) is central to health and disease status.
It depends on complex regulatory networks of two major interconnected proteolytic degradation pathways: the ubiquitin-proteasome (UPS) and autophagy systems.
Here we will investigate whether a novel proteostasis pathway, called the Intracellular Pathogen Response (IPR), recently identified in the model system Caenorhabditis elegans, is also active in mammalian cells.
In C. elegans the IPR is upregulated during i…
UNIVERSITY OF NEWCASTLE UPON TYNE
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