CORDIS Project
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This project investigates the role of microglia, the brain's immune cells, in aging and neurodegenerative diseases. By using advanced proteomics, it aims to map protein interactions in microglia and macrophages to understand their dysfunction and identify potential therapeutic targets.
Microglia, the brain’s primary macrophages, play essential role in preserving neuronal homeostasis, clearing debris and shaping neural circuits throughout life.
These functions are pivotal, particularly in context of aging and neurodegenerative diseases.
Human genetic studies implicate microglia in age-related neurodegenerative diseases, with alterations in their endolysosomal network emerging as a critical determinant of disease risk.
However, how microglial endolysosomal functions alter during…
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