CORDIS Project
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This project aims to investigate the 3D structure of replicated genomes in individual cells using a new fluorescence technique. It focuses on understanding how cohesin proteins organize chromosomes and their role in DNA repair processes.
The extremely long DNA molecules encoding complex genomes of higher eukaryotes must be organised inside the tiny volume of cells so that the genetic information can be read, maintained, and propagated across cell generations.
Genomic DNA is folded into loops such that contacts between distant DNA elements can mediate transcriptional regulation or assembly of mechanically stiff mitotic chromosomes.
Following DNA replication, each chromosome contains two DNA molecules, which interact with each oth…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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