CORDIS Project
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MICROBOTS investigates the role of gut microbiomes in improving outcomes for patients undergoing stem cell transplants. The project aims to identify microbial signatures that enhance immune responses and tissue regeneration, potentially transforming treatment protocols for graft-versus-host disease and cancer therapies…
Allogeneic stem cell transplantation (allo-SCT) is the most common cellular immunotherapy for hematologic malignancies, but beneficial outcomes are limited by severe morbidity and mortality by graft-vs.-host disease (GVHD) and by relapse as a consequence of insufficient antitumor immune response (graft-vs-leukemia, GVL).
In allo-SCT patients, a diverse gut microbiome is associated with beneficial clinical outcomes and fecal microbiota transplantation (FMT) emerges as a promising therapeutic opti…
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