CORDIS Project
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This project investigates how gut bacteria influence the effectiveness of immune checkpoint inhibitors in cancer treatment. It aims to develop a novel therapeutic approach using bacteria-derived extracellular vesicles to enhance immune responses against tumors, ultimately paving the way for new clinical applications in…
Emerging evidence from cancer patients and mouse models indicates that gut bacteria affect response to immune checkpoint inhibitors (ICI).
As a result, modification of gut bacteria by dietary changes, probiotics and fecal transplantations are explored but a huge gap remains to gain clinical application.
Limiting factors are the lack of mechanistic knowledge on how gut bacteria impact ICI response, the need of antibiotics to treat infections in cancer patients and gut resilience to exogenous bact…
UNIVERSITEIT GENT
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