CORDIS Project
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The Micro-SENSE project develops an advanced 3D bioelectronic model of the human nose-brain axis to enhance understanding of nasal physiology and its role in brain diseases. This platform integrates nasal organoids, olfactory tissue, and advanced monitoring technologies to study drug delivery and microbiome interaction…
Olfactory neurons allow circumventing the blood-brain barrier making this route particularly interesting for the non-invasive intranasal treatment of brain diseases (Alzheimer’s Disease).
Moreover, commensal nasal microbes present in the respiratory region, the major surface of the nasal cavity, are assumed to induce health-promoting effects via metabolites as the gut or skin microbiome does.
These complex nasal host-microbiome interactions are emphasized when considering that olfactory neurons…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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