CORDIS Project
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This project investigates the role of the intestinal microbiome in liver fibrosis, focusing on how microbial metabolites influence liver cell behavior. By analyzing these interactions, the research aims to uncover mechanisms that could lead to new therapies for managing liver fibrosis.
Liver fibrosis is increasing in prevalence in many Western populations (mainly due to alcoholic liver disease and non-alcoholic fatty liver disease) and has a major burden on care provision as to date there is no specific intervention to reverse fibrosis.
One of the factors that could regulate liver fibrosis is the intestinal microbiome, as various microbial derived compounds reach the liver through the portal vein and act on the liver cells including stellate and Kupffer cells, the main drivers…
WEIZMANN INSTITUTE OF SCIENCE
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