CORDIS Project
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This project uses Cryo Electron Tomography to study the biogenesis and degradation of Major Histocompatibility Complex-I, crucial for immune responses. It aims to provide insights into protein folding and degradation processes, potentially identifying new targets for diseases related to cellular stress.
One third of the cell proteome utilizes the secretory pathway for entrance into the endoplasmic reticulum (ER).
However, the insertion of nascent proteins into or their translocation across the ER membrane, their maturation and assembly to oligomeric complexes and their degradation are very basic cellular processes of which we largely lack an integrative structural insight.I propose to use Cryo Electron Tomography (CET) to unravel the molecular mechanism of the biogenesis and degradation of Majo…
UNIVERSITEIT UTRECHT
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