CORDIS Project
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This project focuses on developing inhibitors to reverse immune suppression caused by aberrant glycosylation in cancer cells. By designing multivalent ligands that target specific carbohydrate-binding receptors, the aim is to enhance cancer immunotherapy effectiveness.
The appearance of aberrant glycans on the tumor cell surface is one of the emerging hallmarks of cancer.
Tumor growth is accompanied by tumor evasion of the immune system which limits the efficacy of cancer vaccines.
However, and despite the fact that aberrant tumor glycosylation alters how the immune system perceives the tumor and, can also induce immunosuppressive signaling through glycan-binding receptors, the role of tumor glycosylation in immune evasion has mostly been overlooked.
It is cle…
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
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