CORDIS Project
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This project investigates how certain bacterial cells survive antibiotic treatment, focusing on the metabolic adaptations of 'pre-resistant' cells in Pseudomonas aeruginosa and Acinetobacter baumannii. By using advanced proteomics and gene editing techniques, it aims to uncover mechanisms that contribute to the develop…
Antimicrobial resistance (AMR) is a rising global health threat and rapid evolution of resistance against existing or newly developed antibacterial compounds is predicted to lead to 10 million deaths and $60 trillion of lost economic output by 2050.
While resistance-conferring mutations, their inheritance and spread by horizontal gene transfer are increasingly well-studied, our understanding of “pre-resistant” cells’ survival and resilience in the presence of lethal antibacterial doses remains u…
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