CORDIS Project
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This project focuses on developing a new method for ring-opening cross-metathesis to convert small cyclic compounds into acyclic dienes with high selectivity. The resulting compounds will facilitate the rapid synthesis of bioactive molecules, enhancing drug discovery processes in medicinal chemistry.
Catalytic olefin metathesis is a transformative transformation with many unique attributes, one being the possibility of converting a ring to a modifiable acyclic diene by ring-opening cross-metathesis (ROCM).
However, the existing methods are rare and limited to those that generate E-enoates.
To the best of our knowledge, there are no available methods for ROCM reactions that can be used to access Z-alkenes from reactions involving five- to eight-membered rings.To address this, we will develop…
UNIVERSITE DE STRASBOURG
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