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The METAVASC project investigates how brain blood vessels influence cancer cell behavior during brain metastasis. It employs advanced techniques to understand the vascular environment's role in cancer progression and immune response, aiming to develop new therapies.
Brain metastasis (BrM) is one of the deadliest cancer complications, affecting 30-40% of patients.
When cancer cells migrate from the primary tumor to the brain, they face the critical challenge of adapting to an entirely new microenvironment.
This includes various tissue-resident cell types, a distinct extracellular matrix composition, and more importantly, the challenge of traversing the multiple layers constituting the blood-brain barrier (BBB).
The BBB – composed of the endothelial cells, mu…
ASOCIACION INSTITUTO BIOGIPUZKOA
ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOGIPUZKOA
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