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METAREPAIR investigates how high-fat diets influence prostate cancer aggressiveness by affecting DNA repair mechanisms. The project aims to understand the connection between nutritional metabolism and genomic instability, focusing on the role of epigenetic changes in DNA damage response.
Preclinical and epidemiological studies indicate that some dietary patterns, such as high-fat diet (HFD), are associated with increased risk for many cancers, including prostate cancer (PCa).
However, our mechanistic understanding of the link between diet and cancer remains limited.
To help deconvolute the connection between nutrition and tumorigenesis, METAREPAIR will investigate the role of genomic instability in mediating the effect of nutritional metabolism on PCa aggressiveness. I hypothesi…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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