CORDIS Project
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This project investigates enzyme interactions within a crowded cellular environment by reconstituting a biosynthetic pathway for coenzyme Q. It aims to understand how multiple enzymes coordinate in a metabolon to enhance substrate transfer and product formation, providing insights into cellular biochemistry and enzyme…
Enzymes have been classically investigated as standalone catalysts operating in a relatively diluted milieu.
However, the cell micro-compartments are highly crowded environments and biological catalysis cannot be fully understood on the bases of simple diffusive models.
We are tackling this challenge by reconstituting a full-scale biosynthetic pathway where multiple enzymes coordinate within a metabolon - a structurally defined setting that allows the vectorial transfer of substrates and product…
UNIVERSITA DEGLI STUDI DI PAVIA
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