CORDIS Project
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This project investigates the role of protein destabilization in cancer metastasis. It aims to identify vulnerabilities in tumor cells by studying the interactions between metastasis-promoting proteins and molecular chaperones, ultimately seeking to develop targeted therapies to suppress metastasis.
Mutational heterogeneity bestows tumors with the phenotypic plasticity and adaptability required for expansion.
On the other hand, mutations destabilize proteins – lower stability (metastability) of the tumor proteome must be the inevitable consequence.
We set out to systematically investigate this biochemical aspect of metastasis aiming to uncover and therapeutically exploit specific vulnerabilities resulting from protein destabilization.
We will approach this goal by cataloging associations be…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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