CORDIS Project
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This project investigates the aggregation of amyloid-beta peptide, a key factor in Alzheimer's disease, focusing on its interaction with metals like zinc and copper. Using computer simulations, it aims to understand how these metals influence peptide behavior and potentially contribute to neurotoxicity.
The aggregation of the amyloid-beta peptide (A-beta) into fibrils and successively in plaques is the main event in Alzheimer's disease.
The A-beta originates from a membrane protein called amyloid-precursor protein.
In healthy brain A-beta is present as soluble form and the predominant chains are formed by 40 or 42 amino acids.
The oligomers of A-beta, rather then fully formed fibrils, are suspected to have nerotoxic properties.
The transition metal zinc, copper, iron are present in amyloid plaq…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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