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MetaLeish aims to develop biodegradable metal nanoparticles for treating leishmaniasis, a neglected tropical disease. The project focuses on creating nanoparticles that can effectively target and kill the Leishmania parasites within infected cells, offering a potential new therapy.
Metal nanoparticles have shown high efficacy against various pathogenic microorganisms, including antibiotic-resistant strains, being a very promising solution for the development of novel therapies.
Leishmaniasis is a neglected tropical disease, caused by obligatory intracellular parasites of the Leishmania genus.
In their human host, they thrive inside the acidic environment of parasitophorous vacuole of mononuclear phagocytic cells, such as macrophages.
Leishmaniasis can manifest itself eithe…
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