CORDIS Project
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This project investigates how early-life stress impacts ageing markers in amphibians, particularly focusing on whether metamorphosis can rejuvenate stressed tissues. Using the African clawed frog as a model, it aims to understand the relationship between stress, cellular responses, and ageing throughout complex life cy…
The overall aim of this proposal is to understand how early-life stress can affect later ageing biomarkers (oxidative stress, telomere shortening, and telomerase activity) in species with complex life-cycles, and in particular to test the completely new hypothesis that amphibian metamorphosis may act to rejuvenate tissues previously exposed to stress.
The research objectives are: 1) to determine whether levels of ageing biomarkers vary across larval and metamorphic stages, 2) to investigate whet…
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