CORDIS Project
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This project investigates the relationship between circadian clocks and metabolism in mammals. It aims to understand how metabolic cycles influence the function of circadian rhythms, potentially revealing new insights into metabolic diseases like diabetes and obesity.
The physiology and behavior of mammals are subject to daily oscillations that are driven by an endogenous circadian clock.
The mammalian circadian timing system is composed of a central pacemaker in the brain that is entrained by daily light-dark cycles and in turn synchronizes subsidiary oscillators in virtually all cells of the body.
The core clock molecular circuitry is based on interlocked negative transcription-translation feedback loops that generate daily oscillations of gene expression i…
WEIZMANN INSTITUTE OF SCIENCE
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