CORDIS Project
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This project investigates the sources of nucleotides in cancer cells and their surrounding tissues, focusing on how these cells adapt when nucleotide synthesis is blocked. Using advanced single-cell technologies and mouse models, it aims to uncover metabolic dependencies that could lead to new cancer treatment strategi…
DNA synthesis is essential for cell proliferation.
Nucleotides, the basic building blocks of nucleic acids, are made by nucleotide de novo synthesis (DNS), and DNS disruption is detrimental to rapidly proliferating cancer cells.
Established >70 years ago, anti-nucleotide therapy was one of the first approaches to treat cancer, but it suffers high rate of resistance and relapse. DNS can be bypassed by an uptake of extracellular nucleotides or by recycling in salvage pathways, possibly a reason fo…
IBT INSTITUTE OF BIOTECHNOLOGY AS CRVVI
BIOTECHNOLOGICKY USTAV AV CR VVI
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