CORDIS Project
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This project explores metabolic changes during breast cancer development and metastasis, focusing on the PI3K/AKT pathway. It aims to identify metabolic regulators that facilitate tumor cell migration and invasion, potentially revealing new targets for treatment.
Each year 1.1 million new cases of breast cancer occur among women worldwide and ~50% of the patients succumb to metastatic disease.
Although the biology of metastasis has been intensively studied, the cellular and biochemical mechanisms orchestrating its steps remain largely elusive.
In this proposal, I will study the metabolic rewiring accompanying breast tumorigenesis and metastasis.
Switching of metabolism can be controlled by oncogenic pathways, such as the PI3K/AKT pathway, which is freque…
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