CORDIS Project
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This project investigates how triple negative breast cancer cells interact with bone-forming cells to survive and metastasize. It aims to characterize the metabolism of these cancer cells in the bone and identify potential therapeutic targets to limit bone metastasis.
Triple negative breast cancer cells (TNBC) metastasize to the bone, resulting in progressive bone destruction and severe complications for the patient. TNBC colonize the bone already much earlier, but they often stay dormant for several years and remain undetectable.
Recent studies showed that at this early stage, TNBC cells are in close proximity to bone-forming cells (osteoblasts), and this interaction promotes TNBC survival and proliferation.
Interestingly, recent findings also indicate that…
KATHOLIEKE UNIVERSITEIT LEUVEN
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