CORDIS Project
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This project investigates the molecular and cellular mechanisms of mental retardation, focusing on how genetic factors affect synaptic function and glutamate receptor dynamics. It aims to understand the role of Rho GTPase signaling in neuronal connectivity and plasticity related to cognitive deficits.
Mental retardation (MR) imposes a major medical and social-economical problem in our society.
It is defined as a global reduction in cognitive and intellectual abilities, which manifests before the age of 18, and is estimated to affect 1-3% of the population.
The causes of MR are extremely heterogeneous and include non-genetic factors as well as genetic changes that include chromosomal abnormalities and single-gene mutations.
Great progress has been made over recent years towards the identificat…
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