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The MERA project investigates a novel photoreceptor, Rhodopsin-guanylyl-cyclase, to enhance optogenetics by enabling targeted cell inactivation. It aims to characterize this photoreceptor and develop tools for broader applications in neuroscience.
Channelrhodopsin, which was discovered and described as a light-gated ion channel in my laboratory, has revolutionized the field of neuroscience over the past decade by enabling researchers to specifically activate selected neurons in a large ensemble of neuronal cells with short light flashes, a technology we now call ""Optogenetics."" However, though highly desirable, the inactivation of specific cells using moderate or low light intensities is not yet possible.
The recently discovered rhodops…
HUMBOLDT-UNIVERSITAET ZU BERLIN
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