CORDIS Project
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This project explores the regulation of platelet production and reactivity, challenging the notion that mechanical forces are the primary drivers. It investigates intrinsic and extrinsic mechanisms that control megakaryocyte activity, aiming to develop new therapeutic tools for platelet-related diseases.
Platelets are highly reactive fragments of megakaryocytes (MKs) that have been implicated in all major pathophysiological processes, but the molecular mechanisms controlling the number and reactivity of platelets in the circulation remain incompletely defined.
The prevailing thinking is that mechanical forces are the primary drivers of platelet production, but the logic is flawed and the evidence contradictory.
What is glaringly overlooked are intrinsic inhibitory mechanisms and extrinsic cues p…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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