CORDIS Project
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This project investigates how membrane tension at the plasma membrane is regulated, focusing on the role of the Target of Rapamycin Complex 2 and the lipophilic molecule palmitoylcarnitine. By identifying key proteins involved in this process, the research aims to enhance our understanding of cellular homeostasis and i…
Maintenance of membrane tension at the plasma membrane (PM) is an important yet understudied aspect of cellular homeostasis.
Dysregulated membrane tension homeostasis has roles in cancer, neurodegeneration, and metabolic syndrome but its study has been limited by a lack of tools to measure and manipulate it.
The Target of Rapamycin Complex 2 (TORC2), an important signaling hub regulating cell growth, has an unexpected role in maintaining PM tension homeostasis. A screen for TORC2-specific inhibi…
UNIVERSITE DE GENEVE
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