CORDIS Project
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This research aims to uncover the biophysical mechanisms that regulate the arrangement of signaling proteins in T cells during immune responses. By utilizing advanced microscopy techniques, it seeks to understand how protein clustering influences T cell activation and its implications for therapeutic development.
The overall aim of this project is to identify key biophysical mechanisms that control the spatial arrangement of signalling proteins and membrane lipids in the regulation of T cell activation.
During an immune response, T cells are activated in response to antigenic peptides in a process that requires the formation of multi-molecular signalling complexes.
It is known that many T cell signalling proteins (such as the kinase Lck and the scaffold protein LAT) are not randomly distributed within th…
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