CORDIS Project
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This project seeks to understand how similar proteins are distributed in different membrane domains, influencing cellular functions. By studying SNARE proteins, it aims to reveal the mechanisms behind protein partitioning and membrane organization.
My goal is to elucidate how structurally closely-related proteins are selectively partitioned in distinct membrane domains that allow localization, clustering and segregation of specific cellular activities.
Although many of the mechanisms that govern membrane organization are increasingly well understood, such as lipid ‘rafts’ or protein-anchoring to the cortical cytoskeleton, these mechanisms are not sufficiently specific to account for the partitioning of closely homologous proteins in separa…
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