CORDIS Project
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This project investigates the mechanisms controlling memory cell diversity in T cell immunity, focusing on the role of T cell receptors in generating effective immune responses. It aims to develop new models for studying memory cells and their implications for vaccine strategies against diseases like cancer and influen…
T cell mediated immunity protects us against pathogens and cancer.
The naïve T cell pool consists of millions of clones, each one unique based on its T cell receptor (TCR).
Upon infection, only a few of these clones are recruited to generate antigen-specific memory.
Selection of memory clones is a trade-off between specificity and diversity; too much specificity restricts antigen-recognition, which precludes responsiveness against pathogens with small mutations.
Too much diversity impairs effici…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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