CORDIS Project
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This research aims to uncover the molecular mechanisms behind 'fasting memory' in mammals, which may enhance health benefits associated with intermittent fasting. By profiling gene expression and chromatin changes, the project seeks to understand how fasting influences future physiological responses.
Adaptation to recurring environmental challenges (food availability, seasonal rhythms etc.) is a mainstay of physiology.
As such, mammals are exquisitely fitted to tolerate frequent bouts of fasting owing to hepatic production of fuels (glucose, ketones).
Indeed, studies show significant health benefits of intermittent fasting.
Due to the reliance of the fasting response on chromatin and transcriptional regulation, I hypothesize that mammals adapt to recurring fasting by sensitizing transcripti…
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