CORDIS Project
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This project focuses on developing new methods to study how membrane proteins fold and assemble in living cells. By combining chemical biology and protein engineering, it aims to understand the interactions and kinetics involved in membrane protein integration and stability.
Membrane proteins are central players in many if not most cellular processes: cell-cell interaction, signal transduction, nerve conduction, small molecule transport, macromolecular trafficking, etc. A growing number of high-resolution membrane protein structures provide important insights not only into function but also into the general structural constraints imposed by the lipid bilayer.
In contrast, almost no information is available concerning how membrane proteins fold in vivo.
Mainly, this…
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