CORDIS Project
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This project investigates the impact of dietary habits and the drug metformin on preventing age-related chronic diseases. It aims to conduct a trial to evaluate whether metformin, with or without calorie restriction, can reduce the incidence of diseases like cancer and diabetes in older adults at risk.
Age–related chronic diseases (ArCD) are complex non-linear processes that depends on a large number of interconnected genetic and metabolic pathways which should be tackled with a many faceted preventive strategy.
Calorie-dense diet and sedentary lifestyle are responsible of the growing prevalence of metabolic syndrome (MetS), which, together with tobacco, is the major preventable cause of ArCD, mediated by the increased availability of insulin, growth factors, and inflammatory cytokines.
In ani…
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
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