CORDIS Project
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This project investigates how membrane transport proteins, specifically the GltPh transporter, change shape to move substances across cell membranes. By using advanced structural biology techniques, it aims to reveal the mechanisms behind these conformational changes, which are crucial for understanding how similar tra…
The alternating access model of how membrane-embedded transport proteins translocate substrates across biological membranes has been proposed since the 1960s: membrane transporters bind substrates on one side of the membrane and release them on the other side upon conformational rearrangements in the protein.
This has been experimentally confirmed by high-resolution structures of membrane transporters in different conformations and is exemplified by the conformational change in the archaeal glut…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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United States, Ithaca Ny
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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