CORDIS Project
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This project investigates how cells manage protein and lipid production to prevent stress in the endoplasmic reticulum, which is linked to various diseases. It focuses on understanding the role of membrane proteins in cellular responses and aims to develop tools for studying these processes.
All cells must balance the production of proteins and lipids to maintain membrane functions.
Imbalances in protein folding and lipid metabolism cause endoplasmic reticulum (ER) stress associated with a wide range of complex diseases including diabetes, neurodegeneration, and viral infections.
The central homeostatic program of the ER is the unfolded protein response (UPR), which senses unfolded proteins in the ER to control protein synthesis, chaperone abundance, and lipid metabolism.
Through th…
UNIVERSITAT DES SAARLANDES
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