CORDIS Project
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This project investigates the role of microRNAs in the differentiation and cell death of early mouse embryos. By analyzing specific microRNA families, the research aims to enhance understanding of embryonic development and potential therapeutic applications using embryonic stem cells.
A number of crucial events involved in embryo patterning occur during early post-implantation development in mammals.
These include the differentiation of the pluripotent epiblast into the different embryo lineages, the specification of the body axes and morphogenetic events such as the cavitation of the embryo by programmed cell death.
Embryonic Stem (ES) cells derived from the undifferentiated epiblast represent a powerful tool for the development of new therapies, however to successfully mani…
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