CORDIS Project
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This project aims to identify chaperones that assist in the folding of membrane proteins within the endoplasmic reticulum. By studying ABC transporters, it seeks to uncover the mechanisms of membrane protein assembly, which could lead to advancements in treating diseases related to protein misfolding.
Membrane proteins constitute about 30 % of the eukaryotic proteome and are involved in crucial processes such as transporting molecules across membranes, mediating intracellular trafficking and functioning as signalling receptors.
Most membrane proteins of varied topologies and functions are assembled in the endoplasmic reticulum (ER).
While a lot is known about the protein quality control machinery in the ER, most studies have focussed on soluble lumenal proteins or domains that are accessible…
UNIVERSITEIT UTRECHT
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